Changes in amino acid concentrations in rat brain after pretreatment with neuroleptic drugs and picrotoxin [proceedings].

Fig. 1. Effect of chlorpromazine and reserpine on the arterio-venous dflerence of glutamine and glutamate during qtrerent electrical stimulation Blood samples from the femoral artery and the transverse sinum contralateral to the stimulated plexus were taken simultaneously in the course of the second minute of stimulation, or before stimulation. The stimulation was performed 60min after a single dose injection of compound CPZ (5mg/kg body wt.) or reserpine (0.5mg/kg body wt.) dissolved in 1.5ml of saline. Bars represent the mean concentrations in pmo1/100ml of plasma f S.E.M. for the numbers of animals indicated in parentheses. Open bars are results for controls and filled bars are results after afferent electrical stimulation.